Organization · Venture Capital
Spruce Capital Partners, LLC
Spruce Capital Partners, LLC is a venture capital firm based in San Francisco that focuses on investing in innovative life sciences companies addressing health, wellness, and environmental challenges. The firm co-manages the MLS Capital Fund II, targeting investments in biotechnology and sustainable agriculture.
Overview
What Spruce Capital Partners, LLC does
What Spruce Capital Partners, LLC is
Spruce Capital Partners, LLC is a venture capital firm based in San Francisco that focuses on investing in innovative life sciences companies addressing health, wellness, and environmental challenges. The firm co-manages the MLS Capital Fund II, targeting investments in biotechnology and sustainable agriculture.
How it participates in the startup ecosystem
The current public profile supports funder capabilities. Each capability below is shown separately so organization identity and role-specific information do not get conflated.
Operational profile
Organization status and context
Organization status describes the entity itself. Funding and program availability appear within the relevant capability profile.
- Operational status
- Active
- Organization type
- Venture Capital
- Structured capabilities
- Funder
- Last reviewed
- April 22, 2026
Official channels
Find Spruce Capital Partners, LLC elsewhere
Open the official website or a supported primary organization account.
Capability profile
Spruce Capital Partners, LLC as a funder
Investment thesis
Spruce Capital Partners focuses on investing in innovative life sciences companies that address global challenges in health, wellness, and environmental sustainability.
Focus narrative
The firm primarily invests in life sciences companies that develop solutions to improve health and wellness while positively impacting the environment. Spruce Capital Partners co-manages the MLS Capital Fund II, which supports various investments in this sector, focusing on biogreentech, including plant and animal agriculture, food and nutrition, bio-renewable chemicals, and synthetic biology.
Value beyond capital
Spruce Capital Partners adds value to its portfolio companies through extensive industry expertise, strategic guidance, and access to a network of resources in the life sciences sector. The firm's focus on innovative solutions allows it to support companies in navigating challenges and achieving sustainable growth.
Terms and economics
- Typical check
- $20,000,000–$55,000,000
- Sweet spot
- $30,000,000
Focus and fit
- Stages
- Series A · Series B · Series C · Series E
- Regions
- North AmericaAsia
Availability
- Currently deploying
- Yes
Portfolio and track record
- Recorded portfolio count
- 9
- Recorded notable exits
- GreenLight Biosciences
Portfolio context
AGERpoint: Develops data tools for creating detailed 3D models of agricultural assets using LiDAR and hyperspectral scans. Amfora: Focuses on nutritionally-enhanced crops for food and animal feed. Consumer Physics: Created a pocket-sized near-infrared spectrometer for analyzing objects based on chemical composition. Crop Enhancement: Applies green chemical formulations to protect crops from pests and fungal growth. Evolve: Develops microbiome-based products aimed at improving the health trajectory of newborn infants. GreenLight: Innovates low-cost RNA production processes for agricultural pest control. Inscripta: Designs instruments that automate the CRISPR gene editing method. Pivot Bio: Develops plant microbiome-based products for plant nutrition. Provivi: Utilizes bio-catalysis processes to produce insect pheromones for pest control.
Common questions
What to know about Spruce Capital Partners, LLC
Upseed classifies Spruce Capital Partners, LLC under the Venture Capital organization type. Its current public profile includes funder capabilities.
Source and update disclosure
Know what this page is based on
Source basis
Public organization and program material, official websites, and structured Upseed records.
Last reviewed
April 22, 2026
Known limits
Capability profiles appear only when a structured public profile also contains decision-useful role evidence. Terms and availability can change.
Upseed is an independent guide. It is not affiliated with or endorsed by the organization described on this page.