Organization · Venture Capital
Lionheart Ventures
Lionheart Ventures is a San Francisco-based venture capital firm that invests in transformative technologies, focusing on artificial intelligence and frontier mental health solutions. Founded in 2019, it aims to mitigate civilizational risks through ethical investment practices.
Overview
What Lionheart Ventures does
What Lionheart Ventures is
Lionheart Ventures is a San Francisco-based venture capital firm that invests in transformative technologies, focusing on artificial intelligence and frontier mental health solutions. Founded in 2019, it aims to mitigate civilizational risks through ethical investment practices.
How it participates in the startup ecosystem
The current public profile supports funder capabilities. Each capability below is shown separately so organization identity and role-specific information do not get conflated.
Operational profile
Organization status and context
Organization status describes the entity itself. Funding and program availability appear within the relevant capability profile.
- Operational status
- Active
- Organization type
- Venture Capital
- Founded
- Founded in 2019
- Approximate age
- About 7 years
- Structured capabilities
- Funder
- Last reviewed
- March 30, 2026
Official channels
Find Lionheart Ventures elsewhere
Open the official website or a supported primary organization account.
Capability profile
Lionheart Ventures as a funder
Investment thesis
Lionheart Ventures focuses on the development of transformative technologies, particularly in AI and frontier mental health. Their investment thesis emphasizes responsible development to enhance human flourishing and address global challenges.
Focus narrative
Lionheart Ventures primarily invests in two sectors: artificial intelligence and frontier mental health technologies. Their focus is on companies that develop transformative solutions to enhance human well-being and address significant global challenges, such as the mental health crisis. They seek to generate attractive returns for investors while promoting responsible technology development.
Value beyond capital
Lionheart Ventures adds value to its portfolio companies through a deep bench of operators, neuroscientists, and AI safety experts. They provide strategic guidance, access to a network of industry leaders, and support in navigating the complexities of developing transformative technologies.
Terms and economics
- Typical check
- $100,000–$5,000,000
- Sweet spot
- $1,500,000
Focus and fit
- Stages
- Seed · Series A · Series B
- Regions
- Global · United States
Availability
- Currently deploying
- Yes
Portfolio and track record
- Recorded portfolio count
- 14
Portfolio context
Notable portfolio companies include: Anthropic: Specializes in AI safety and large language models. Calm: A global mental wellness application designed to help users manage stress and meditate. Reconnect Labs: A clinical-stage pharmaceutical company focused on psychedelic therapeutics for mental health. Cognigenics: Utilizes genetic neuroengineering technology to treat mental health disorders. Bexson Biomedical: Develops non-opioid therapies for acute pain management. Breathwrk: An app offering breathing exercises to improve health and performance.
Common questions
What to know about Lionheart Ventures
Upseed classifies Lionheart Ventures under the Venture Capital organization type. Its current public profile includes funder capabilities.
Source and update disclosure
Know what this page is based on
Source basis
Public organization and program material, official websites, and structured Upseed records.
Last reviewed
March 30, 2026
Known limits
Capability profiles appear only when a structured public profile also contains decision-useful role evidence. Terms and availability can change.
Upseed is an independent guide. It is not affiliated with or endorsed by the organization described on this page.