Organization · Venture Capital
Lewis & Clark Ventures
Lewis & Clark Ventures is a St. Louis-based venture capital firm that invests in late seed to Series A B2B software companies, focusing on regions often overlooked by traditional coastal funds.
Overview
What Lewis & Clark Ventures does
What Lewis & Clark Ventures is
Lewis & Clark Ventures is a St. Louis-based venture capital firm that invests in late seed to Series A B2B software companies, focusing on regions often overlooked by traditional coastal funds.
How it participates in the startup ecosystem
The current public profile supports funder capabilities. Each capability below is shown separately so organization identity and role-specific information do not get conflated.
Operational profile
Organization status and context
Organization status describes the entity itself. Funding and program availability appear within the relevant capability profile.
- Operational status
- Active
- Organization type
- Venture Capital
- Structured capabilities
- Funder
- Last reviewed
- March 18, 2026
Official channels
Find Lewis & Clark Ventures elsewhere
Open the official website or a supported primary organization account.
Capability profile
Lewis & Clark Ventures as a funder
Investment thesis
Lewis & Clark Ventures partners with entrepreneurs to build B2B software companies, focusing on overlooked geographies.
Focus narrative
The firm invests in late seed through Series A B2B software companies, typically providing initial funding between $2 million and $3 million, with flexibility in either direction. Lewis & Clark Ventures seeks to empower entrepreneurs and support the development of transformative software solutions.
Value beyond capital
Lewis & Clark Ventures adds value to its portfolio companies through strategic guidance, operational support, and access to a network of industry connections. The firm leverages its team's experience as former founders and operators to help entrepreneurs navigate challenges and scale their businesses effectively.
Terms and economics
- Typical check
- $2,000,000–$3,000,000
- Sweet spot
- $2,500,000
Focus and fit
- Stages
- Seed · Seed+ · Series A · Series B
- Regions
- North AmericaUnited States
Availability
- Currently deploying
- Yes
Portfolio and track record
- Recorded portfolio count
- 40
Portfolio context
Notable portfolio companies include: Amper: Solutions provider in its sector. ArborXR: Specializes in XR technology solutions. Beam Benefits: Offers benefits management solutions. Benson Hill: Works in agricultural technology. Big Squid: Provides data science solutions. Blindspot: Focuses on data integration and analytics. ChatLingual: Offers language translation services. Dalia: A recruiting technology platform. GreenLight: Works in biosciences. Kaizen Health: Provides healthcare solutions. MedAvail: Focuses on pharmacy technology. Occuspace: Offers occupancy intelligence solutions. PayGround: A healthcare payment network. Sailes: Recognized technology company. Springbuk: Provides healthcare analytics. TomoCredit: Offers credit solutions. Waldo Photos: A photography service.
Common questions
What to know about Lewis & Clark Ventures
Upseed classifies Lewis & Clark Ventures under the Venture Capital organization type. Its current public profile includes funder capabilities.
Source and update disclosure
Know what this page is based on
Source basis
Public organization and program material, official websites, and structured Upseed records.
Last reviewed
March 18, 2026
Known limits
Capability profiles appear only when a structured public profile also contains decision-useful role evidence. Terms and availability can change.
Upseed is an independent guide. It is not affiliated with or endorsed by the organization described on this page.