Organization · Venture Capital
Endurance28
Endurance28 is a venture capital firm based in San Francisco, focusing on early-stage investments in sectors such as climate, health, and the digital economy. It aims to empower entrepreneurs addressing significant global challenges.
Overview
What Endurance28 does
What Endurance28 is
Endurance28 is a venture capital firm based in San Francisco, focusing on early-stage investments in sectors such as climate, health, and the digital economy. It aims to empower entrepreneurs addressing significant global challenges.
How it participates in the startup ecosystem
The current public profile supports funder capabilities. Each capability below is shown separately so organization identity and role-specific information do not get conflated.
Operational profile
Organization status and context
Organization status describes the entity itself. Funding and program availability appear within the relevant capability profile.
- Operational status
- Active
- Organization type
- Venture Capital
- Structured capabilities
- Funder
- Last reviewed
- April 22, 2026
Official channels
Find Endurance28 elsewhere
Open the official website or a supported primary organization account.
Capability profile
Endurance28 as a funder
Investment thesis
Backs ambitious entrepreneurs tackling the world's most difficult challenges in Climate, Health, and the Digital Economy. Focuses on overlooked opportunities where disciplined, resourceful founders can generate outsized returns.
Focus narrative
Endurance28 invests in sectors including climate and environment, digital economy, and health and well-being. The firm prioritizes environmental resilience, healthcare improvement, and the empowerment of small and medium-sized businesses (SMBs). Their investment strategy is designed to align with the needs and goals of founders, ensuring a collaborative partnership.
Value beyond capital
Endurance28 provides a founder-first orientation, emphasizing resilience and perseverance in entrepreneurs. The firm aims to partner closely with portfolio companies, offering strategic guidance and support to navigate challenges and capitalize on opportunities in their respective markets.
Focus and fit
- Stages
- Pre-seed · Seed
- Regions
- North AmericaLatin America
Availability
- Currently deploying
- Yes
Portfolio and track record
- Recorded portfolio count
- 30
Portfolio context
Notable portfolio companies include: Clip: A company operating in the digital economy sector. Encellin: Focused on health and well-being. JÜSTO: Engaged in innovative food solutions. Compound Foods: Specializes in sustainable food production. Prixz: A digital economy venture. Gen1e Lifesciences: Works in the health sector. Holoclara: Focuses on health and well-being innovations, first investment of Fund III. Cubbo Biosolutions: Engaged in biotechnology. Dprotein: Works on protein-related innovations. Biomakers: Focuses on sustainable materials.
Common questions
What to know about Endurance28
Upseed classifies Endurance28 under the Venture Capital organization type. Its current public profile includes funder capabilities.
Source and update disclosure
Know what this page is based on
Source basis
Public organization and program material, official websites, and structured Upseed records.
Last reviewed
April 22, 2026
Known limits
Capability profiles appear only when a structured public profile also contains decision-useful role evidence. Terms and availability can change.
Upseed is an independent guide. It is not affiliated with or endorsed by the organization described on this page.