Organization · Venture Capital
City Hill Ventures
City Hill Ventures is an impact-focused venture capital firm based in San Diego, California, primarily investing in the healthcare sector, with a growing interest in cleantech and media & entertainment.
Overview
What City Hill Ventures does
What City Hill Ventures is
City Hill Ventures is an impact-focused venture capital firm based in San Diego, California, primarily investing in the healthcare sector, with a growing interest in cleantech and media & entertainment.
How it participates in the startup ecosystem
The current public profile supports funder capabilities. Each capability below is shown separately so organization identity and role-specific information do not get conflated.
Operational profile
Organization status and context
Organization status describes the entity itself. Funding and program availability appear within the relevant capability profile.
- Operational status
- Active
- Organization type
- Venture Capital
- Founded
- Founded in 2010
- Approximate age
- About 16 years
- Structured capabilities
- Funder
- Last reviewed
- March 18, 2026
Official channels
Find City Hill Ventures elsewhere
Open the official website or a supported primary organization account.
Capability profile
City Hill Ventures as a funder
Investment thesis
City Hill Ventures is dedicated to investing in mission-driven for-profit and non-profit initiatives, primarily in the healthcare sector, with a focus on seed and early-stage companies.
Focus narrative
City Hill Ventures primarily invests in the healthcare sector, targeting seed and early-stage investments in private life sciences and healthcare technology enterprises. The firm has also expanded its focus to include cleantech and media & entertainment industries, with investment amounts typically ranging from $100,000 to $5 million.
Value beyond capital
City Hill Ventures adds value to its portfolio companies through strategic guidance, access to a network of industry experts, and support in navigating the complexities of the healthcare and life sciences sectors.
Terms and economics
- Typical check
- $100,000–$5,000,000
Focus and fit
- Stages
- Seed
- Regions
- United States
Availability
- Currently deploying
- Yes
Portfolio and track record
- Recorded portfolio count
- 15
- Recorded notable exits
- Eclipse Therapeutics, Inhibrx, Ignyta, Flex Pharma, Erasca, and Black Diamond Therapeutics
Portfolio context
City Hill Ventures has invested in notable companies such as Eclipse Therapeutics (acquired by Bionomics), Inhibrx (IPO), Ignyta (acquired by Roche), Flex Pharma (IPO), and Erasca (IPO). Other portfolio companies include NovaBay Pharmaceuticals, Medenovo, Patara Pharma, and Black Diamond Therapeutics (IPO).
Common questions
What to know about City Hill Ventures
Upseed classifies City Hill Ventures under the Venture Capital organization type. Its current public profile includes funder capabilities.
Source and update disclosure
Know what this page is based on
Source basis
Public organization and program material, official websites, and structured Upseed records.
Last reviewed
March 18, 2026
Known limits
Capability profiles appear only when a structured public profile also contains decision-useful role evidence. Terms and availability can change.
Upseed is an independent guide. It is not affiliated with or endorsed by the organization described on this page.