Organization · Venture Capital
Breakout Ventures
Breakout Ventures is a San Francisco-based venture capital firm that invests in early-stage companies focused on scientific innovation in biotech, deep tech, and hard tech sectors. They partner with founders to build transformative solutions in human health and sustainability.
Overview
What Breakout Ventures does
What Breakout Ventures is
Breakout Ventures is a San Francisco-based venture capital firm that invests in early-stage companies focused on scientific innovation in biotech, deep tech, and hard tech sectors. They partner with founders to build transformative solutions in human health and sustainability.
How it participates in the startup ecosystem
The current public profile supports funder and publisher capabilities. Each capability below is shown separately so organization identity and role-specific information do not get conflated.
Operational profile
Organization status and context
Organization status describes the entity itself. Funding and program availability appear within the relevant capability profile.
- Operational status
- Active
- Organization type
- Venture Capital
- Founded
- Founded in 2016
- Approximate age
- About 10 years
- Structured capabilities
- Funder · Publisher
- Last reviewed
- March 31, 2026
Official channels
Find Breakout Ventures elsewhere
Open the official website or a supported primary organization account.
Capability profile
Breakout Ventures as a funder
Investment thesis
Breakout Ventures invests in science-driven companies at the intersection of biology, chemistry, computation, and AI, focusing on early-stage innovations that can lead to significant market impact.
Focus narrative
Breakout Ventures targets early-stage companies within the life sciences and industrial markets. The firm is particularly interested in backing founders who are pursuing novel hypotheses that can lead to significant opportunities and scalable impact. Their investment strategy is characterized by high-conviction bets on scientific innovation, aiming to identify inflection points before they gain market recognition.
Value beyond capital
Breakout Ventures adds value to its portfolio companies through deep operator and scientific expertise, providing strategic guidance and support in navigating the complexities of scientific innovation and market entry.
Terms and economics
- Typical check
- $500,000–$5,000,000
Focus and fit
- Stages
- Pre-seed · Seed · Series A
- Regions
- United States
Availability
- Currently deploying
- Yes
Portfolio and track record
- Recorded notable exits
- Surf Bio
Portfolio context
Notable portfolio companies include: Cytovale: A clinical diagnostic company that identifies sepsis by measuring biophysical markers of single cells. Noetik: Develops cancer immunotherapies using advanced machine learning methods. Immusoft: Genetically modifies B cells to create sustained protein-producing therapeutics. Twelve: Transforms carbon dioxide emissions into essential products. Modern Meadow: Innovates in sustainable biofabrication. Ecovative Design: Develops mycelium-grown materials for plant-based meats and textiles. STRM.BIO: Specializes in in vivo gene therapy. Additional companies include Phantom Neuro, Stealth Co, Epana Bio, and Zymochem.
Capability profile
Breakout Ventures as a publisher
Editorial focus
Breakout Ventures is focused on investing in science-driven companies, particularly in the life sciences and industrial markets. The organization aims to support founders innovating at the intersection of biology, chemistry, computation, and artificial intelligence. Their investment thesis emphasizes urgency and execution in transforming scientific advancements into market solutions.
Audience value
Breakout Ventures provides significant financial backing and expertise to early-stage companies, helping them navigate the complexities of scientific innovation and market entry.
Format and cadence
- Content formats
- newsletter
- Primary platform
- breakout.vc
Availability
- Guest pitch state
- Not currently accepting
Audience and focus
- Audience
- Founders · Investors
- Regions
- United States
Flagship work and coverage
Flagship properties
Breakout Ventures manages multiple funds, including Fund I launched in 2016, Fund II with undisclosed details, and Fund III, which is their largest at $114M, closed in 2025/2026.
Notable coverage
Breakout Ventures has been featured in various articles highlighting their portfolio companies and investment strategies, including notable successes like Cytovale, Surf Bio, and ZymoChem.
Common questions
What to know about Breakout Ventures
Upseed classifies Breakout Ventures under the Venture Capital organization type. Its current public profile includes funder and publisher capabilities.
Source and update disclosure
Know what this page is based on
Source basis
Public organization and program material, official websites, and structured Upseed records.
Last reviewed
March 31, 2026
Known limits
Capability profiles appear only when a structured public profile also contains decision-useful role evidence. Terms and availability can change.
Upseed is an independent guide. It is not affiliated with or endorsed by the organization described on this page.