Organization · Venture Capital
645 Ventures
645 Ventures is an early-stage venture capital firm based in New York and San Francisco, focusing on Seed and Series A investments in technology companies. The firm utilizes a data-informed approach through its proprietary Voyager platform.
Overview
What 645 Ventures does
What 645 Ventures is
645 Ventures is an early-stage venture capital firm based in New York and San Francisco, focusing on Seed and Series A investments in technology companies. The firm utilizes a data-informed approach through its proprietary Voyager platform.
How it participates in the startup ecosystem
The current public profile supports funder and publisher capabilities. Each capability below is shown separately so organization identity and role-specific information do not get conflated.
Operational profile
Organization status and context
Organization status describes the entity itself. Funding and program availability appear within the relevant capability profile.
- Operational status
- Active
- Organization type
- Venture Capital
- Founded
- Founded in 2013
- Approximate age
- About 13 years
- Structured capabilities
- Funder · Publisher
- Last reviewed
- March 16, 2026
Official channels
Find 645 Ventures elsewhere
Open the official website or a supported primary organization account.
Capability profile
645 Ventures as a funder
Investment thesis
645 Ventures partners with founders to support the growth of innovative companies, focusing on software applications that empower knowledge workers and enhance customer experiences.
Focus narrative
645 Ventures invests in themes such as Citizen Professional, SaaS for the 2nd Wave, Engineering Value Chain Revolution, and Personalized Consumer. The firm is particularly interested in software applications that enhance productivity, cloud-based solutions for un-penetrated business areas, open source ecosystems, and consumer companies that utilize personalized data.
Value beyond capital
645 Ventures adds value to its portfolio companies through strategic guidance, leveraging data-driven insights, and providing access to a network of resources and expertise that help accelerate growth and innovation.
Terms and economics
- Typical check
- $1,000,000–$20,000,000
- Sweet spot
- $5,000,000
Focus and fit
- Stages
- Seed · Series A · Series B
- Regions
- Global · North America
Availability
- Currently deploying
- Yes
Portfolio and track record
- Recorded portfolio count
- 75
- Investments in the last 12 months
- 8
- Last recorded investment
- October 16, 2025
- Recorded notable exits
- Iterable, Eden Health, FiscalNote, Panther Labs, and Resident
Portfolio context
Notable portfolio companies include: Goldbelly: Nationwide delivery of gourmet local food. FiscalNote: Helps companies navigate legislative changes. Iterable: A cross-channel growth marketing platform. Panther Labs: Provides cloud-native security information and event management (SIEM). Resident: Comprehensive home furnishing solutions. Squire: A platform for barbershops to manage bookings and payments.
Capability profile
645 Ventures as a publisher
Editorial focus
645 Ventures is a venture capital firm that partners with founders to build innovative technology companies. The firm invests across various sectors, focusing on themes such as empowering knowledge workers through new software applications, supporting cloud-based software adoption in previously un-penetrated business areas, investing in open-source ecosystems and API-driven software applications, and enhancing customer experiences through personalized data.
Audience value
645 Ventures provides strategic support and resources to founders, helping them navigate challenges and scale their businesses effectively.
Format and cadence
- Content formats
- blog
- Primary platform
- Website
Availability
- Guest pitch state
- Not currently accepting
Audience and focus
- Audience
- Founders
- Sectors
- SaaS & Cloud Software
- Regions
- North AmericaUnited States
Flagship work and coverage
Flagship properties
645 Ventures publishes articles on their website discussing industry insights and predictions, and they are committed to sharing resources and supporting community causes through their initiative, 645 Cares.
Common questions
What to know about 645 Ventures
Upseed classifies 645 Ventures under the Venture Capital organization type. Its current public profile includes funder and publisher capabilities.
Source and update disclosure
Know what this page is based on
Source basis
Public organization and program material, official websites, and structured Upseed records.
Last reviewed
March 16, 2026
Known limits
Capability profiles appear only when a structured public profile also contains decision-useful role evidence. Terms and availability can change.
Upseed is an independent guide. It is not affiliated with or endorsed by the organization described on this page.