Organization · Venture Studio
25madison
25madison is a New York-based venture platform that incubates and invests in early-stage startups, particularly in AI-native software and tech-enabled businesses. It also engages in transformation buyouts of lower-middle market companies.
Overview
What 25madison does
What 25madison is
25madison is a New York-based venture platform that incubates and invests in early-stage startups, particularly in AI-native software and tech-enabled businesses. It also engages in transformation buyouts of lower-middle market companies.
How it participates in the startup ecosystem
The current public profile supports funder and program host capabilities. Each capability below is shown separately so organization identity and role-specific information do not get conflated.
Operational profile
Organization status and context
Organization status describes the entity itself. Funding and program availability appear within the relevant capability profile.
- Operational status
- Active
- Organization type
- Venture Studio
- Founded
- Founded in 2025
- Approximate age
- About 1 year
- Structured capabilities
- Funder · Program host
- Last reviewed
- May 2, 2026
What Venture studio means
A venture studio is an organization that systematically creates new startups by generating or sourcing ideas, validating them, building early products, recruiting founders or operators, providing shared resources, and retaining meaningful equity in the companies it helps create.
Open the glossary entryOfficial channels
Find 25madison elsewhere
Open the official website or a supported primary organization account.
Capability profile
25madison as a funder
Investment thesis
25madison focuses on applying artificial intelligence to modernize legacy businesses, investing in early-stage ventures and transforming lower-middle market companies through AI.
Focus narrative
The organization invests in early-stage opportunities, providing incubation services for AI-native software and technology-enabled businesses. Their investment strategy emphasizes leveraging AI to modernize traditional industries and improve operational efficiencies.
Value beyond capital
25madison adds value to its portfolio companies through its incubation services, operational expertise, and connections within the private equity network, which can facilitate customer access and acquisition pathways.
Focus and fit
- Stages
- Pre-seed · Seed · Series A
- Regions
- United StatesNorth America
Availability
- Currently deploying
- Yes
Portfolio and track record
Portfolio context
Notable portfolio companies include: Basalt Health: An AI-powered healthcare assistant. Canopy: Wearable personal safety technology for healthcare staff. Clear: A comprehensive pricing and payments platform for healthcare. Croissant: Offers guaranteed resale value before purchase. Eon: Natural language processing for radiology reports. Flourish: Virtual mental health care for teens and young adults. FlyteHealth: Focuses on changing perceptions and treatment of obesity. Gratia: A compensation platform for health employers. Kouper Health: Discharge case management software for hospitals. Thrive: A mobile platform providing connectivity for Medicaid patients.
Capability profile
25madison as a program host
Program thesis
25madison is an investment platform focused on applying artificial intelligence (AI) to modernize legacy businesses. The organization aims to leverage AI to enhance operational efficiencies and modernize traditional industries.
Focus narrative
25madison invests in early-stage venture opportunities and provides incubation services for AI-native software and technology-enabled businesses. The organization also engages in transformation buyouts, focusing on lower-middle market businesses.
Value and support
25madison offers a combination of venture funding, incubation services, and access to a network of private equity relationships that can accelerate growth and operational leverage for startups.
Additional public guidance
Q: What stages does 25madison invest in? A: 25madison invests in pre-seed to Series A stages. Q: What sectors does 25madison focus on? A: The organization focuses on B2B software, healthcare, AI-native software, supply chain, and industrials.
Availability
- Application state
- Accepting
Focus and fit
- Stages
- Pre-seed · Seed · Series A
- Regions
- North AmericaUnited States
Alumni and track record
Alumni context
Notable portfolio companies include Basalt Health, an AI-powered healthcare assistant; Canopy, wearable personal safety technology for healthcare staff; and Flourish, a virtual mental health care platform for teens and young adults.
Common questions
What to know about 25madison
Upseed classifies 25madison under the Venture Studio organization type. Its current public profile includes funder and program host capabilities.
Source and update disclosure
Know what this page is based on
Source basis
Public organization and program material, official websites, and structured Upseed records.
Last reviewed
May 2, 2026
Known limits
Capability profiles appear only when a structured public profile also contains decision-useful role evidence. Terms and availability can change.
Upseed is an independent guide. It is not affiliated with or endorsed by the organization described on this page.